Gene description for Trim25
Gene name tripartite motif-containing 25
Gene symbol Trim25
Other names/aliases Efp
Znf147
Species Rattus norvegicus
 Database cross references - Trim25
ExoCarta ExoCarta_494338
Entrez Gene 494338
 Trim25 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Trim25
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    zinc ion binding GO:0008270 IEA
    molecular_function GO:0003674 ND
Biological Process
    regulation of viral release from host cell GO:1902186 ISO
    response to vitamin D GO:0033280 IEP
    innate immune response GO:0045087 ISO
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO
    response to estrogen GO:0043627 IEP
    negative regulation of viral entry into host cell GO:0046597 ISO
    negative regulation of viral release from host cell GO:1902187 ISO
    regulation of viral entry into host cell GO:0046596 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
    cellular_component GO:0005575 ND
 Experiment description of studies that identified Trim25 in exosomes
1
Experiment ID 90
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70|HSP90|TSG101
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Trim25
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trim25 is involved
No pathways found





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