Gene description for Pdcd10
Gene name programmed cell death 10
Gene symbol Pdcd10
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pdcd10
ExoCarta ExoCarta_494345
Entrez Gene 494345
UniProt Q6NX65  
 Pdcd10 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Pdcd10
Molecular Function
    protein N-terminus binding GO:0047485 ISO
    protein homodimerization activity GO:0042803 ISO
    protein kinase binding GO:0019901 ISO
Biological Process
    angiogenesis GO:0001525 IEA
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of stress-activated MAPK cascade GO:0032874 ISO
    stress fiber assembly GO:0043149 ISO
    positive regulation of cell proliferation GO:0008284 ISS
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    establishment of Golgi localization GO:0051683 ISO
    wound healing, spreading of cells GO:0044319 ISO
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 ISO
    response to hydrogen peroxide GO:0042542 ISO
    intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:0036481 ISO
    Golgi reassembly GO:0090168 ISO
    negative regulation of apoptotic process GO:0043066 ISS
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 ISO
    negative regulation of gene expression GO:0010629 ISO
    positive regulation of Notch signaling pathway GO:0045747 ISO
    regulation of Rho protein signal transduction GO:0035023 ISO
    protein stabilization GO:0050821 ISO
    positive regulation of MAP kinase activity GO:0043406 ISS
Subcellular Localization
    Golgi apparatus GO:0005794 ISO
    extracellular exosome GO:0070062 ISO
    Golgi membrane GO:0000139 IEA
    plasma membrane GO:0005886 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISS
 Experiment description of studies that identified Pdcd10 in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pdcd10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pdcd10 is involved
No pathways found





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