Gene description for TIFAB
Gene name TRAF-interacting protein with forkhead-associated domain, family member B
Gene symbol TIFAB
Other names/aliases -
Species Homo sapiens
 Database cross references - TIFAB
ExoCarta ExoCarta_497189
Vesiclepedia VP_497189
Entrez Gene 497189
HGNC 34024
MIM 612663
UniProt Q6ZNK6  
 TIFAB identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TIFAB
Molecular Function
    protein binding GO:0005515 IPI
    deubiquitinase activator activity GO:0035800 IEA
Biological Process
    toll-like receptor signaling pathway GO:0002224 IEA
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    thorax and anterior abdomen determination GO:0007356 IGI
    regulation of gene expression GO:0010468 IEA
    trigeminal nerve development GO:0021559 IGI
    vestibulocochlear nerve formation GO:0021650 IGI
    myeloid cell differentiation GO:0030099 IEA
    peristalsis GO:0030432 IGI
    auditory behavior GO:0031223 IGI
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    genitalia morphogenesis GO:0035112 IGI
    inner ear morphogenesis GO:0042472 IGI
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
    regulation of muscle organ development GO:0048634 IGI
    genitalia development GO:0048806 IGI
    inner ear development GO:0048839 IGI
    neuromuscular process controlling balance GO:0050885 IGI
    mastication GO:0071626 IGI
    cochlea development GO:0090102 IGI
    cochlea morphogenesis GO:0090103 IGI
    craniofacial suture morphogenesis GO:0097094 IGI
    learned vocalization behavior GO:0098583 IGI
    negative regulation of relaxation of muscle GO:1901078 IGI
    regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902238 IEA
    negative regulation of saliva secretion GO:1905747 IGI
    hard palate morphogenesis GO:1905748 IGI
 Experiment description of studies that identified TIFAB in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TIFAB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TIFAB is involved
No pathways found





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