Gene description for Xdh
Gene name xanthine dehydrogenase
Gene symbol Xdh
Other names/aliases XOR
Species Rattus norvegicus
 Database cross references - Xdh
ExoCarta ExoCarta_497811
Entrez Gene 497811
UniProt P22985  
 Xdh identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Xdh
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    molybdopterin cofactor binding GO:0043546 ISS
    xanthine oxidase activity GO:0004855 ISS
    2 iron, 2 sulfur cluster binding GO:0051537 ISS
    electron carrier activity GO:0009055 IEA
    xanthine dehydrogenase activity GO:0004854 ISO
    iron ion binding GO:0005506 IEA
    oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0016903 IBA
    oxidoreductase activity GO:0016491 ISO
    UDP-N-acetylmuramate dehydrogenase activity GO:0008762 IEA
    flavin adenine dinucleotide binding GO:0050660 ISS
Biological Process
    negative regulation of protein kinase B signaling GO:0051898 ISO
    positive regulation of p38MAPK cascade GO:1900745 ISO
    negative regulation of protein phosphorylation GO:0001933 ISO
    negative regulation of gene expression GO:0010629 ISO
    regulation of epithelial cell differentiation GO:0030856 ISO
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISO
    xanthine catabolic process GO:0009115 ISS
    negative regulation of vasculogenesis GO:2001213 ISO
    lactation GO:0007595 ISO
    negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 ISO
    oxidation-reduction process GO:0055114 ISO
    response to aluminum ion GO:0010044 IDA
    negative regulation of endothelial cell proliferation GO:0001937 ISO
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
    negative regulation of endothelial cell differentiation GO:0045602 ISO
    bone resorption GO:0045453 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    peroxisome GO:0005777 IEA
    sarcoplasmic reticulum GO:0016529 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Xdh in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Xdh
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Xdh is involved
No pathways found





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