Gene description for Cps1
Gene name carbamoyl-phosphate synthetase 1
Gene symbol Cps1
Other names/aliases cps
Species Rattus norvegicus
 Database cross references - Cps1
ExoCarta ExoCarta_497840
Vesiclepedia VP_497840
Entrez Gene 497840
UniProt P07756  
 Cps1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cps1
Molecular Function
    carbamoyl-phosphate synthase (ammonia) activity GO:0004087 IBA
    carbamoyl-phosphate synthase (ammonia) activity GO:0004087 IDA
    carbamoyl-phosphate synthase (ammonia) activity GO:0004087 ISO
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity GO:0004088 IBA
    endopeptidase activity GO:0004175 IDA
    calcium ion binding GO:0005509 IPI
    ATP binding GO:0005524 IDA
    phospholipid binding GO:0005543 IDA
    phospholipid binding GO:0005543 IPI
    glutamate binding GO:0016595 IPI
    potassium ion binding GO:0030955 ISO
    small molecule binding GO:0036094 ISO
    protein-containing complex binding GO:0044877 IDA
    metal ion binding GO:0046872 ISO
    modified amino acid binding GO:0072341 ISO
Biological Process
    urea cycle GO:0000050 IDA
    liver development GO:0001889 IEP
    'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA
    glutamine metabolic process GO:0006541 IBA
    midgut development GO:0007494 IEP
    response to xenobiotic stimulus GO:0009410 IEP
    response to toxic substance GO:0009636 IEP
    response to zinc ion GO:0010043 IEP
    response to amine GO:0014075 IEP
    triglyceride catabolic process GO:0019433 ISO
    response to food GO:0032094 IEP
    response to lipopolysaccharide GO:0032496 IEP
    response to lipopolysaccharide GO:0032496 ISO
    response to glucagon GO:0033762 IEP
    response to oleic acid GO:0034201 IEP
    vasodilation GO:0042311 ISO
    response to starvation GO:0042594 IEP
    response to amino acid GO:0043200 IEP
    cellular response to fibroblast growth factor stimulus GO:0044344 IEP
    nitric oxide metabolic process GO:0046209 ISO
    response to steroid hormone GO:0048545 IEP
    homocysteine metabolic process GO:0050667 ISO
    response to glucocorticoid GO:0051384 IEP
    response to cAMP GO:0051591 IEP
    monoatomic anion homeostasis GO:0055081 IDA
    response to growth hormone GO:0060416 IEP
    hepatocyte differentiation GO:0070365 IEP
    carbamoyl phosphate biosynthetic process GO:0070409 ISO
    cellular response to ammonium ion GO:0071242 ISO
    cellular response to cAMP GO:0071320 IEP
    cellular response to glucagon stimulus GO:0071377 IEP
    cellular response to oleic acid GO:0071400 IEP
    response to dexamethasone GO:0071548 IEP
Subcellular Localization
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IDA
    plasma membrane GO:0005886 IEA
    protein-containing complex GO:0032991 IDA
    mitochondrial nucleoid GO:0042645 ISO
 Experiment description of studies that identified Cps1 in exosomes
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cps1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cps1 is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Urea cycle IEA Reactome





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