Gene description for Svip
Gene name small VCP/p97-interacting protein
Gene symbol Svip
Other names/aliases RGD1565432
Species Rattus norvegicus
 Database cross references - Svip
ExoCarta ExoCarta_499157
Entrez Gene 499157
UniProt P0C0A9  
 Svip identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Svip
Molecular Function
    protein self-association GO:0043621 ISO
Biological Process
    positive regulation of protein lipidation GO:1903061 ISO
    negative regulation of protein complex assembly GO:0031333 ISO
    negative regulation of retrograde protein transport, ER to cytosol GO:1904153 ISO
    positive regulation of autophagy GO:0010508 ISO
    negative regulation of ER-associated ubiquitin-dependent protein catabolic process GO:1903070 ISO
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 ISO
    Golgi membrane GO:0000139 IEA
    plasma membrane GO:0005886 IEA
    Hrd1p ubiquitin ligase complex GO:0000836 ISO
    extracellular exosome GO:0070062 ISO
    smooth endoplasmic reticulum membrane GO:0030868 IEA
 Experiment description of studies that identified Svip in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Svip
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Svip is involved
No pathways found





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