Gene description for Gdf3
Gene name growth differentiation factor 3
Gene symbol Gdf3
Other names/aliases RGD1564178
Species Rattus norvegicus
 Database cross references - Gdf3
ExoCarta ExoCarta_500311
Entrez Gene 500311
 Gdf3 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Gdf3
Molecular Function
    cytokine activity GO:0005125 IBA
    molecular_function GO:0003674 ND
    growth factor activity GO:0008083 IEA
    protein kinase binding GO:0019901 ISO
    transforming growth factor beta receptor binding GO:0005160 IBA
Biological Process
    signal transduction GO:0007165 ISO
    BMP signaling pathway GO:0030509 IBA
    SMAD protein signal transduction GO:0060395 IBA
    endoderm development GO:0007492 ISO
    response to dietary excess GO:0002021 ISO
    primitive streak formation GO:0090009 ISO
    regulation of cell fate commitment GO:0010453 ISO
    notochord development GO:0030903 ISO
    regulation of MAPK cascade GO:0043408 IBA
    cell development GO:0048468 IBA
    mesoderm development GO:0007498 ISO
    negative regulation of myoblast differentiation GO:0045662 ISO
    eye development GO:0001654 ISO
    negative regulation of epidermal cell differentiation GO:0045605 ISO
    regulation of apoptotic process GO:0042981 IBA
    skeletal system development GO:0001501 ISO
    growth GO:0040007 IEA
    in utero embryonic development GO:0001701 ISO
    negative regulation of BMP signaling pathway GO:0030514 ISO
    biological_process GO:0008150 ND
    somite rostral/caudal axis specification GO:0032525 ISO
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
    formation of anatomical boundary GO:0048859 ISO
Subcellular Localization
    cellular_component GO:0005575 ND
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Gdf3 in exosomes
1
Experiment ID 93
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|GAPDH
EV Cytosolic markers
✔
CD9|CD151
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method RT-PCR
Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Gdf3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gdf3 is involved
No pathways found





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