Gene description for Ybx1
Gene name Y box binding protein 1
Gene symbol Ybx1
Other names/aliases Byb1
Cbfa
Dbpb
Ef1a
Msy1
Nsep1
Yb1
Species Rattus norvegicus
 Database cross references - Ybx1
ExoCarta ExoCarta_500538
Entrez Gene 500538
UniProt P62961  
 Ybx1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ybx1
Molecular Function
    RNA binding GO:0003723 ISS
    transcription factor binding GO:0008134 IPI
    single-stranded DNA binding GO:0003697 ISO
    sequence-specific DNA binding GO:0043565 IDA
    GTPase binding GO:0051020 ISO
    chromatin binding GO:0003682 ISO
    DNA binding GO:0003677 ISO
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
    p53 binding GO:0002039 IMP
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    mRNA binding GO:0003729 IPI
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    RNA splicing GO:0008380 IEA
    CRD-mediated mRNA stabilization GO:0070934 ISS
    in utero embryonic development GO:0001701 ISO
    positive regulation of cell proliferation GO:0008284 IMP
    positive regulation of cell division GO:0051781 IEA
    negative regulation of apoptotic process GO:0043066 IDA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of insulin receptor signaling pathway GO:0046627 IMP
    regulation of transcription, DNA-templated GO:0006355 ISO
    negative regulation of striated muscle cell differentiation GO:0051154 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    mRNA processing GO:0006397 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nuclear membrane GO:0031965 ISO
    cytoplasmic stress granule GO:0010494 ISS
    ribonucleoprotein complex GO:0030529 ISS
    CRD-mediated mRNA stability complex GO:0070937 ISO
    extracellular region GO:0005576 IEA
    histone pre-mRNA 3'end processing complex GO:0071204 ISS
    messenger ribonucleoprotein complex GO:1990124 IDA
    dendrite GO:0030425 IDA
    extracellular exosome GO:0070062 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    U12-type spliceosomal complex GO:0005689 ISO
    nucleus GO:0005634 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified Ybx1 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ybx1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ybx1 is involved
No pathways found





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