Gene description for SPPL2B
Gene name signal peptide peptidase like 2B
Gene symbol SPPL2B
Other names/aliases -
Species Bos taurus
 Database cross references - SPPL2B
ExoCarta ExoCarta_504285
Vesiclepedia VP_504285
Entrez Gene 504285
 SPPL2B identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SPPL2B
Molecular Function
    aspartic endopeptidase activity, intramembrane cleaving GO:0042500 IEA
Biological Process
    membrane protein proteolysis GO:0033619 IEA
Subcellular Localization
    lysosomal membrane GO:0005765 IEA
    Golgi-associated vesicle membrane GO:0030660 IEA
    lumenal side of endoplasmic reticulum membrane GO:0098553 IEA
    cytoplasmic side of endoplasmic reticulum membrane GO:0098554 IEA
 Experiment description of studies that identified SPPL2B in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SPPL2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SPPL2B is involved
No pathways found





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