Gene description for NOX3
Gene name NADPH oxidase 3
Gene symbol NOX3
Other names/aliases GP91-3
MOX-2
Species Homo sapiens
 Database cross references - NOX3
ExoCarta ExoCarta_50508
Entrez Gene 50508
HGNC 7890
MIM 607105
UniProt Q9HBY0  
 NOX3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for NOX3
Molecular Function
    superoxide-generating NADPH oxidase activity GO:0016175 IEA
Biological Process
    otolith development GO:0048840 IEA
    oxidation-reduction process GO:0055114 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
    superoxide anion generation GO:0042554 IEA
    temperature homeostasis GO:0001659 IEA
    detection of gravity GO:0009590 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    NADPH oxidase complex GO:0043020 IEA
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified NOX3 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for NOX3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NOX3 is involved
PathwayEvidenceSource
RHO GTPases Activate NADPH Oxidases TAS Reactome





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