Gene description for PHGDH
Gene name phosphoglycerate dehydrogenase
Gene symbol PHGDH
Other names/aliases -
Species Bos taurus
 Database cross references - PHGDH
ExoCarta ExoCarta_505103
Entrez Gene 505103
UniProt Q5EAD2  
 PHGDH identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PHGDH
Molecular Function
    NAD binding GO:0051287 IEA
    phosphoglycerate dehydrogenase activity GO:0004617 IEA
Biological Process
    glial cell development GO:0021782 IEA
    neural tube development GO:0021915 IEA
    glycine metabolic process GO:0006544 IEA
    oxidation-reduction process GO:0055114 IEA
    gamma-aminobutyric acid metabolic process GO:0009448 IEA
    taurine metabolic process GO:0019530 IEA
    G1 to G0 transition GO:0070314 IEA
    threonine metabolic process GO:0006566 IEA
    L-serine biosynthetic process GO:0006564 IEA
    regulation of gene expression GO:0010468 IEA
    spinal cord development GO:0021510 IEA
    glutamine metabolic process GO:0006541 IEA
    neuron projection development GO:0031175 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PHGDH in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PHGDH
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PHGDH is involved
PathwayEvidenceSource
Serine biosynthesis IEA Reactome





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