Gene description for Lats2
Gene name large tumor suppressor 2
Gene symbol Lats2
Other names/aliases 4932411G09Rik
AV277261
AW228608
Species Mus musculus
 Database cross references - Lats2
ExoCarta ExoCarta_50523
Entrez Gene 50523
UniProt Q7TSJ6  
 Lats2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lats2
Molecular Function
    metal ion binding GO:0046872 IEA
    protein serine/threonine kinase activity GO:0004674 ISO
    nucleotide binding GO:0000166 IEA
    kinase activity GO:0016301 IEA
    ATP binding GO:0005524 ISO
    protein kinase activity GO:0004672 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    transferase activity GO:0016740 IEA
Biological Process
    cellular protein localization GO:0034613 IGI
    hippo signaling GO:0035329 ISO
    intracellular signal transduction GO:0035556 ISO
    phosphorylation GO:0016310 IEA
    hormone-mediated signaling pathway GO:0009755 ISO
    mitotic nuclear division GO:0007067 IEA
    G1/S transition of mitotic cell cycle GO:0000082 ISO
    cell division GO:0051301 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 ISO
    keratinocyte differentiation GO:0030216 IGI
    protein phosphorylation GO:0006468 ISO
    regulation of organ growth GO:0046620 IMP
    cell cycle GO:0007049 IEA
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    intracellular GO:0005622 IGI
    microtubule organizing center GO:0005815 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    spindle pole GO:0000922 ISO
 Experiment description of studies that identified Lats2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lats2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lats2 is involved
PathwayEvidenceSource
Signaling by Hippo IEA Reactome





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