Gene description for SLC9A3R1
Gene name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Gene symbol SLC9A3R1
Other names/aliases EBP50
NHERF-1
Species Bos taurus
 Database cross references - SLC9A3R1
ExoCarta ExoCarta_505242
Entrez Gene 505242
UniProt Q3SZK8  
 SLC9A3R1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SLC9A3R1
Molecular Function
    growth factor receptor binding GO:0070851 IEA
    phosphatase binding GO:0019902 IEA
    dopamine receptor binding GO:0050780 IEA
    beta-catenin binding GO:0008013 IEA
    protein self-association GO:0043621 IEA
    beta-2 adrenergic receptor binding GO:0031698 IEA
    chloride channel regulator activity GO:0017081 ISS
    PDZ domain binding GO:0030165 IEA
Biological Process
    renal absorption GO:0070293 ISS
    negative regulation of sodium:proton antiporter activity GO:0032416 IEA
    regulation of protein kinase activity GO:0045859 ISS
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 ISS
    bile acid secretion GO:0032782 ISS
    glutathione transport GO:0034635 ISS
    Wnt signaling pathway GO:0016055 IEA
    microvillus assembly GO:0030033 IEA
    cellular protein localization GO:0034613 IEA
    renal sodium ion transport GO:0003096 IEA
    negative regulation of cell motility GO:2000146 ISS
    negative regulation of cell proliferation GO:0008285 IEA
    actin cytoskeleton organization GO:0030036 IEA
    negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 ISS
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IEA
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 IEA
    renal phosphate ion absorption GO:0097291 IEA
    cellular phosphate ion homeostasis GO:0030643 IEA
    adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IEA
    regulation of excretion GO:0044062 IEA
    negative regulation of protein kinase B signaling GO:0051898 ISS
    negative regulation of cell migration GO:0030336 IEA
Subcellular Localization
    microvillus membrane GO:0031528 ISS
    extracellular exosome GO:0070062 IEA
    intracellular membrane-bounded organelle GO:0043231 IEA
    apical plasma membrane GO:0016324 IEA
    brush border membrane GO:0031526 IEA
    endomembrane system GO:0012505 IEA
    microvillus GO:0005902 ISS
    ruffle GO:0001726 IEA
    cytoplasm GO:0005737 ISS
    sperm midpiece GO:0097225 ISS
    membrane GO:0016020 ISS
    centrosome GO:0005813 IEA
    cell periphery GO:0071944 ISS
    filopodium GO:0030175 IEA
 Experiment description of studies that identified SLC9A3R1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC9A3R1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC9A3R1 is involved
No pathways found





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