Gene description for Ero1l
Gene name ERO1-like (S. cerevisiae)
Gene symbol Ero1l
Other names/aliases ERO1-L
Species Mus musculus
 Database cross references - Ero1l
ExoCarta ExoCarta_50527
Vesiclepedia VP_50527
Entrez Gene 50527
UniProt Q8R180  
 Ero1l identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ero1l
Molecular Function
    oxidoreductase activity GO:0016491 ISO
    protein disulfide isomerase activity GO:0003756 IEA
    peptide-methionine (R)-S-oxide reductase activity GO:0033743 IEA
    methionine-R-sulfoxide reductase activity GO:0070191 IEA
    protein disulfide oxidoreductase activity GO:0015035 IDA
    oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0016671 IEA
    peptide-methionine (S)-S-oxide reductase activity GO:0008113 IEA
Biological Process
    protein maturation by protein folding GO:0022417 IGI
    release of sequestered calcium ion into cytosol GO:0051209 IMP
    oxidation-reduction process GO:0055114 IDA
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IMP
    4-hydroxyproline metabolic process GO:0019471 IGI
    protein folding GO:0006457 ISO
    response to endoplasmic reticulum stress GO:0034976 IDA
    chaperone mediated protein folding requiring cofactor GO:0051085 ISO
    brown fat cell differentiation GO:0050873 IDA
    apoptotic process GO:0006915 IEA
    endoplasmic reticulum unfolded protein response GO:0030968 IDA
    cell redox homeostasis GO:0045454 IGI
    extracellular matrix organization GO:0030198 IGI
    transport GO:0006810 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    membrane GO:0016020 ISO
    integral component of endoplasmic reticulum membrane GO:0030176 ISO
    intracellular GO:0005622 IMP
    cell GO:0005623 IGI
    cytosol GO:0005829 IMP
 Experiment description of studies that identified Ero1l in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ero1l
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ero1l is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome
Insulin processing IEA Reactome





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