Gene description for APOA2
Gene name apolipoprotein A-II
Gene symbol APOA2
Other names/aliases -
Species Bos taurus
 Database cross references - APOA2
ExoCarta ExoCarta_505394
Entrez Gene 505394
UniProt P81644  
 APOA2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for APOA2
Molecular Function
    cholesterol transporter activity GO:0017127 IEA
    cholesterol binding GO:0015485 IEA
    high-density lipoprotein particle binding GO:0008035 IEA
    apolipoprotein receptor binding GO:0034190 IEA
    protein heterodimerization activity GO:0046982 ISS
    protein homodimerization activity GO:0042803 IEA
    phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IEA
    lipase inhibitor activity GO:0055102 IEA
    high-density lipoprotein particle receptor binding GO:0070653 IEA
    triglyceride binding GO:0017129 NAS
    phosphatidylcholine binding GO:0031210 IEA
Biological Process
    cholesterol homeostasis GO:0042632 IEA
    protein oxidation GO:0018158 IEA
    negative regulation of lipid catabolic process GO:0050995 IEA
    negative regulation of cholesterol transporter activity GO:0060695 IEA
    phospholipid efflux GO:0033700 IEA
    low-density lipoprotein particle remodeling GO:0034374 IEA
    cholesterol efflux GO:0033344 IEA
    lipoprotein metabolic process GO:0042157 IEA
    positive regulation of catalytic activity GO:0043085 IEA
    phosphatidylcholine biosynthetic process GO:0006656 IEA
    phospholipid catabolic process GO:0009395 IEA
    protein folding GO:0006457 IEA
    negative regulation of cholesterol import GO:0060621 IEA
    positive regulation of lipid catabolic process GO:0050996 IEA
    high-density lipoprotein particle remodeling GO:0034375 IEA
    negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 IEA
    high-density lipoprotein particle clearance GO:0034384 IEA
    reverse cholesterol transport GO:0043691 IEA
    triglyceride-rich lipoprotein particle remodeling GO:0034370 IEA
    cholesterol metabolic process GO:0008203 IEA
    high-density lipoprotein particle assembly GO:0034380 IEA
    defense response to bacterium GO:0042742 IEA
    regulation of protein stability GO:0031647 IEA
    response to glucose GO:0009749 IEA
    diacylglycerol catabolic process GO:0046340 IEA
    positive regulation of interleukin-8 biosynthetic process GO:0045416 ISS
    regulation of intestinal cholesterol absorption GO:0030300 IEA
    negative regulation of cytokine secretion involved in immune response GO:0002740 IEA
    positive regulation of cholesterol esterification GO:0010873 IEA
    peptidyl-methionine modification GO:0018206 IEA
    negative regulation of lipase activity GO:0060192 IEA
Subcellular Localization
    blood microparticle GO:0072562 IEA
    very-low-density lipoprotein particle GO:0034361 IEA
    extracellular exosome GO:0070062 IEA
    spherical high-density lipoprotein particle GO:0034366 IEA
    chylomicron GO:0042627 IEA
 Experiment description of studies that identified APOA2 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for APOA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which APOA2 is involved
Chylomicron-mediated lipid transport IEA Reactome
Retinoid metabolism and transport IEA Reactome

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