Gene description for PVRL2
Gene name poliovirus receptor-related 2 (herpesvirus entry mediator B)
Gene symbol PVRL2
Other names/aliases prr2
Species Bos taurus
 Database cross references - PVRL2
ExoCarta ExoCarta_505580
Vesiclepedia VP_505580
Entrez Gene 505580
 PVRL2 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PVRL2
Molecular Function
    cell adhesion molecule binding GO:0050839 IEA
Biological Process
    acrosome assembly GO:0001675 IEA
    positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860 IEA
    positive regulation of immunoglobulin mediated immune response GO:0002891 IEA
    cytoskeleton organization GO:0007010 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    fusion of virus membrane with host plasma membrane GO:0019064 IEA
    positive regulation of mast cell activation GO:0033005 IEA
    susceptibility to natural killer cell mediated cytotoxicity GO:0042271 IEA
    regulation of viral entry into host cell GO:0046596 IEA
    coreceptor-mediated virion attachment to host cell GO:0046814 IEA
    positive regulation of T cell receptor signaling pathway GO:0050862 IEA
    establishment of mitochondrion localization GO:0051654 IEA
    susceptibility to T cell mediated cytotoxicity GO:0060370 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    focal adhesion GO:0005925 IEA
    apical junction complex GO:0043296 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PVRL2 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PVRL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PVRL2 is involved
No pathways found





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