Gene description for Slc23a1
Gene name solute carrier family 23 (ascorbic acid transporter), member 1
Gene symbol Slc23a1
Other names/aliases SVCT1
Species Rattus norvegicus
 Database cross references - Slc23a1
ExoCarta ExoCarta_50621
Entrez Gene 50621
UniProt Q9WTW7  
 Slc23a1 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Slc23a1
Molecular Function
    sodium ion transmembrane transporter activity GO:0015081 ISS
    L-ascorbic acid transporter activity GO:0015229 ISO
    transporter activity GO:0005215 IDA
    L-ascorbate:sodium symporter activity GO:0008520 ISO
    dehydroascorbic acid transporter activity GO:0033300 ISS
    sodium-dependent L-ascorbate transmembrane transporter activity GO:0070890 ISS
Biological Process
    sodium ion transmembrane transport GO:0035725 ISO
    L-ascorbic acid transport GO:0015882 ISO
    sodium ion transport GO:0006814 ISS
    transepithelial L-ascorbic acid transport GO:0070904 ISS
    response to toxic substance GO:0009636 ISS
    dehydroascorbic acid transport GO:0070837 ISS
    vitamin transmembrane transport GO:0035461 ISS
    lung development GO:0030324 ISO
    brain development GO:0007420 ISS
Subcellular Localization
    basal plasma membrane GO:0009925 ISO
    extracellular exosome GO:0070062 ISO
    integral component of plasma membrane GO:0005887 TAS
    cytoplasm GO:0005737 ISO
    apical plasma membrane GO:0016324 ISS
    brush border GO:0005903 IDA
    intracellular organelle GO:0043229 ISS
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Slc23a1 in exosomes
1
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc23a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc23a1 is involved
PathwayEvidenceSource
Vitamin C (ascorbate) metabolism IEA Reactome





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