Gene description for ATIC
Gene name 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene symbol ATIC
Other names/aliases -
Species Bos taurus
 Database cross references - ATIC
ExoCarta ExoCarta_506343
Entrez Gene 506343
UniProt Q0VCK0  
 ATIC identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ATIC
Molecular Function
    phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0004643 IEA
    protein homodimerization activity GO:0042803 ISS
    IMP cyclohydrolase activity GO:0003937 IEA
Biological Process
    'de novo' IMP biosynthetic process GO:0006189 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 IEA
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified ATIC in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATIC
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATIC is involved
PathwayEvidenceSource
Purine ribonucleoside monophosphate biosynthesis IEA Reactome





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