Gene description for Acox1
Gene name acyl-CoA oxidase 1, palmitoyl
Gene symbol Acox1
Other names/aliases RATACOA1
Species Rattus norvegicus
 Database cross references - Acox1
ExoCarta ExoCarta_50681
Entrez Gene 50681
UniProt P07872  
 Acox1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Acox1
Molecular Function
    receptor binding GO:0005102 ISO
    protein N-terminus binding GO:0047485 ISO
    palmitoyl-CoA oxidase activity GO:0016401 ISO
    flavin adenine dinucleotide binding GO:0050660 IEA
    acyl-CoA dehydrogenase activity GO:0003995 IEA
    PDZ domain binding GO:0030165 ISO
    fatty acid binding GO:0005504 IDA
    FAD binding GO:0071949 ISO
    acyl-CoA oxidase activity GO:0003997 ISS
Biological Process
    fatty acid beta-oxidation using acyl-CoA oxidase GO:0033540 ISO
    positive regulation of cholesterol homeostasis GO:2000189 ISO
    very long-chain fatty acid metabolic process GO:0000038 ISO
    peroxisome fission GO:0016559 ISO
    spermatogenesis GO:0007283 ISO
    prostaglandin metabolic process GO:0006693 ISS
    fatty acid beta-oxidation GO:0006635 IEA
    lipid metabolic process GO:0006629 ISS
    fatty acid oxidation GO:0019395 ISS
    lipid homeostasis GO:0055088 ISO
    generation of precursor metabolites and energy GO:0006091 ISS
Subcellular Localization
    mitochondrion GO:0005739 ISO
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 ISO
    peroxisomal membrane GO:0005778 ISO
    peroxisome GO:0005777 ISS
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Acox1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Acox1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acox1 is involved
PathwayEvidenceSource
alpha-linolenic acid (ALA) metabolism IEA Reactome
Beta-oxidation of very long chain fatty acids IEA Reactome





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