Gene description for Hist1h1c
Gene name histone cluster 1, H1c
Gene symbol Hist1h1c
Other names/aliases 0610008C09Rik
H1.2
H1c
H1f2
H1var1
His1a
Species Mus musculus
 Database cross references - Hist1h1c
ExoCarta ExoCarta_50708
Entrez Gene 50708
UniProt P15864  
 Hist1h1c identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
 Gene ontology annotations for Hist1h1c
Molecular Function
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IDA
    chromatin DNA binding GO:0031490 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IGI
    nucleosome positioning GO:0016584 IMP
    nucleosome assembly GO:0006334 IEA
Subcellular Localization
    nuclear euchromatin GO:0005719 ISO
    transcriptionally active chromatin GO:0035327 IDA
    nucleosome GO:0000786 IEA
    nucleus GO:0005634 ISO
    chromosome GO:0005694 IEA
 Experiment description of studies that identified Hist1h1c in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hist1h1c
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hist1h1c is involved
No pathways found





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