Gene description for LTA4H
Gene name leukotriene A4 hydrolase
Gene symbol LTA4H
Other names/aliases -
Species Bos taurus
 Database cross references - LTA4H
ExoCarta ExoCarta_507130
Entrez Gene 507130
UniProt Q3SZH7  
 LTA4H identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for LTA4H
Molecular Function
    metallopeptidase activity GO:0008237 IEA
    zinc ion binding GO:0008270 ISS
    epoxide hydrolase activity GO:0004301 ISS
    aminopeptidase activity GO:0004177 ISS
    leukotriene-A4 hydrolase activity GO:0004463 ISS
    poly(A) RNA binding GO:0044822 IEA
Biological Process
    proteolysis GO:0006508 IEA
    leukotriene biosynthetic process GO:0019370 ISS
    peptide catabolic process GO:0043171 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    extracellular exosome GO:0070062 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified LTA4H in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LTA4H
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LTA4H is involved
PathwayEvidenceSource
Synthesis of Leukotrienes (LT) and Eoxins (EX) IEA Reactome





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