Gene description for SHC1
Gene name SHC (Src homology 2 domain containing) transforming protein 1
Gene symbol SHC1
Other names/aliases p66shc
Species Bos taurus
 Database cross references - SHC1
ExoCarta ExoCarta_507196
Entrez Gene 507196
UniProt Q0IIE2  
 SHC1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SHC1
Molecular Function
    receptor tyrosine kinase binding GO:0030971 IBA
    protein kinase binding GO:0019901 IBA
Biological Process
    insulin receptor signaling pathway GO:0008286 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IBA
    regulation of growth GO:0040008 IEA
    angiogenesis GO:0001525 IEA
    intracellular signal transduction GO:0035556 IEA
    activation of MAPK activity GO:0000187 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified SHC1 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SHC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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