Gene description for SHC1
Gene name SHC (Src homology 2 domain containing) transforming protein 1
Gene symbol SHC1
Other names/aliases p66shc
Species Bos taurus
 Database cross references - SHC1
ExoCarta ExoCarta_507196
Entrez Gene 507196
UniProt Q0IIE2  
 SHC1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SHC1
Molecular Function
    receptor tyrosine kinase binding GO:0030971 IBA
    protein kinase binding GO:0019901 IBA
Biological Process
    insulin receptor signaling pathway GO:0008286 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IBA
    regulation of growth GO:0040008 IEA
    angiogenesis GO:0001525 IEA
    intracellular signal transduction GO:0035556 IEA
    activation of MAPK activity GO:0000187 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified SHC1 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SHC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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