Gene description for SHC1
Gene name SHC (Src homology 2 domain containing) transforming protein 1
Gene symbol SHC1
Other names/aliases p66shc
Species Bos taurus
 Database cross references - SHC1
ExoCarta ExoCarta_507196
Vesiclepedia VP_507196
Entrez Gene 507196
UniProt Q0IIE2  
 SHC1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SHC1
Molecular Function
    receptor tyrosine kinase binding GO:0030971 IEA
Biological Process
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified SHC1 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SHC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SHC1 is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Cell surface interactions at the vascular wall IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
DAP12 interactions IEA Reactome
DAP12 signaling IEA Reactome
Developmental Biology IEA Reactome
Downstream signaling of activated FGFR1 IEA Reactome
Downstream signaling of activated FGFR2 IEA Reactome
Downstream signaling of activated FGFR3 IEA Reactome
Downstream signaling of activated FGFR4 IEA Reactome
Erythropoietin activates RAS IEA Reactome
ESR-mediated signaling IEA Reactome
Extra-nuclear estrogen signaling IEA Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
FCERI mediated MAPK activation IEA Reactome
G alpha (s) signalling events IEA Reactome
GPCR downstream signalling IEA Reactome
GPER1 signaling IEA Reactome
Hemostasis IEA Reactome
IGF1R signaling cascade IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Insulin receptor signalling cascade IEA Reactome
Integrin signaling IEA Reactome
Interleukin receptor SHC signaling IEA Reactome
Interleukin-15 signaling IEA Reactome
Interleukin-2 family signaling IEA Reactome
Interleukin-2 signaling IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
MET activates RAS signaling IEA Reactome
Nervous system development IEA Reactome
Platelet activation, signaling and aggregation IEA Reactome
Platelet Aggregation (Plug Formation) IEA Reactome
RAF/MAP kinase cascade IEA Reactome
RET signaling IEA Reactome
Role of LAT2/NTAL/LAB on calcium mobilization IEA Reactome
SHC-mediated cascade:FGFR1 IEA Reactome
SHC-mediated cascade:FGFR2 IEA Reactome
SHC-mediated cascade:FGFR3 IEA Reactome
SHC-mediated cascade:FGFR4 IEA Reactome
SHC-related events triggered by IGF1R IEA Reactome
SHC1 events in EGFR signaling IEA Reactome
SHC1 events in ERBB2 signaling IEA Reactome
SHC1 events in ERBB4 signaling IEA Reactome
Signal attenuation IEA Reactome
Signal Transduction IEA Reactome
Signaling by ALK IEA Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by EGFR IEA Reactome
Signaling by ERBB2 IEA Reactome
Signaling by ERBB4 IEA Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by FGFR IEA Reactome
Signaling by FGFR1 IEA Reactome
Signaling by FGFR2 IEA Reactome
Signaling by FGFR3 IEA Reactome
Signaling by FGFR4 IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Insulin receptor IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by MET IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IEA Reactome
Signalling to ERKs IEA Reactome
Signalling to RAS IEA Reactome
Tie2 Signaling IEA Reactome





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