Gene description for VAMP8
Gene name vesicle-associated membrane protein 8
Gene symbol VAMP8
Other names/aliases -
Species Bos taurus
 Database cross references - VAMP8
ExoCarta ExoCarta_507309
Entrez Gene 507309
UniProt Q3T0Y8  
 VAMP8 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for VAMP8
Molecular Function
    chloride channel inhibitor activity GO:0019869 IEA
    SNARE binding GO:0000149 IBA
    SNAP receptor activity GO:0005484 IBA
Biological Process
    viral entry into host cell GO:0046718 IEA
    positive regulation of histamine secretion by mast cell GO:1903595 IEA
    protein transport GO:0015031 IEA
    regulation of protein localization to plasma membrane GO:1903076 IEA
    regulation of endocytosis GO:0030100 IEA
    SNARE complex assembly GO:0035493 IEA
    negative regulation of secretion by cell GO:1903531 IEA
    autophagosome fusion GO:0000046 ISS
    mucus secretion GO:0070254 IEA
    vesicle fusion GO:0006906 IBA
    exocytosis GO:0006887 IBA
Subcellular Localization
    late endosome membrane GO:0031902 ISS
    mucin granule GO:0098594 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    recycling endosome GO:0055037 IEA
    lysosomal membrane GO:0005765 ISS
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IEA
    cell surface GO:0009986 IEA
    SNARE complex GO:0031201 ISS
    azurophil granule membrane GO:0035577 IEA
    extracellular exosome GO:0070062 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified VAMP8 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VAMP8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which VAMP8 is involved
PathwayEvidenceSource
Clathrin derived vesicle budding IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here