Gene description for VCP
Gene name valosin containing protein
Gene symbol VCP
Other names/aliases p97
Species Bos taurus
 Database cross references - VCP
ExoCarta ExoCarta_507345
Entrez Gene 507345
UniProt Q3ZBT1  
 VCP identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for VCP
Molecular Function
    hydrolase activity GO:0016787 IEA
    lipid binding GO:0008289 IEA
    ATP binding GO:0005524 IEA
Biological Process
    protein ubiquitination GO:0016567 ISS
    cellular response to DNA damage stimulus GO:0006974 ISS
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 ISS
    double-strand break repair GO:0006302 ISS
    translesion synthesis GO:0019985 ISS
    transport GO:0006810 IEA
    protein N-linked glycosylation via asparagine GO:0018279 ISS
Subcellular Localization
    site of double-strand break GO:0035861 ISS
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified VCP in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VCP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which VCP is involved
No pathways found





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