Gene description for PNPLA2
Gene name patatin-like phospholipase domain containing 2
Gene symbol PNPLA2
Other names/aliases ATGL
Species Bos taurus
 Database cross references - PNPLA2
ExoCarta ExoCarta_508493
Entrez Gene 508493
UniProt Q2KI18  
 PNPLA2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PNPLA2
Molecular Function
    triglyceride lipase activity GO:0004806 ISS
Biological Process
    negative regulation of sequestering of triglyceride GO:0010891 ISS
    positive regulation of triglyceride catabolic process GO:0010898 ISS
    triglyceride catabolic process GO:0019433 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    lipid particle GO:0005811 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified PNPLA2 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PNPLA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PNPLA2 is involved
No pathways found





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