Gene description for PNPLA2
Gene name patatin-like phospholipase domain containing 2
Gene symbol PNPLA2
Other names/aliases ATGL
Species Bos taurus
 Database cross references - PNPLA2
ExoCarta ExoCarta_508493
Vesiclepedia VP_508493
Entrez Gene 508493
UniProt Q2KI18  
 PNPLA2 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PNPLA2
Molecular Function
    triacylglycerol lipase activity GO:0004806 IEA
Biological Process
    positive regulation of triglyceride catabolic process GO:0010898 IEA
    triglyceride catabolic process GO:0019433 IEA
    lipid homeostasis GO:0055088 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    lipid droplet GO:0005811 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified PNPLA2 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PNPLA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PNPLA2 is involved
No pathways found





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