Gene description for STAT3
Gene name signal transducer and activator of transcription 3 (acute-phase response factor)
Gene symbol STAT3
Other names/aliases -
Species Bos taurus
 Database cross references - STAT3
ExoCarta ExoCarta_508541
Entrez Gene 508541
UniProt P61635  
 STAT3 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for STAT3
Molecular Function
    DNA binding GO:0003677 ISS
    signal transducer activity GO:0004871 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein kinase binding GO:0019901 ISS
    protein dimerization activity GO:0046983 ISS
Biological Process
    eye photoreceptor cell differentiation GO:0001754 ISS
    protein import into nucleus GO:0006606 ISS
    interleukin-6-mediated signaling pathway GO:0070102 ISS
    radial glial cell differentiation GO:0060019 ISS
    astrocyte differentiation GO:0048708 ISS
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    transcription, DNA-templated GO:0006351 IEA
    temperature homeostasis GO:0001659 ISS
    phosphorylation GO:0016310 ISS
    sexual reproduction GO:0019953 ISS
    glucose homeostasis GO:0042593 ISS
    regulation of transcription from RNA polymerase II promoter GO:0006357 ISS
    eating behavior GO:0042755 ISS
    JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 ISS
    positive regulation of Notch signaling pathway GO:0045747 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    plasma membrane GO:0005886 ISS
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified STAT3 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STAT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which STAT3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here