Gene description for STAT3
Gene name signal transducer and activator of transcription 3 (acute-phase response factor)
Gene symbol STAT3
Other names/aliases -
Species Bos taurus
 Database cross references - STAT3
ExoCarta ExoCarta_508541
Vesiclepedia VP_508541
Entrez Gene 508541
UniProt P61635  
 STAT3 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for STAT3
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    defense response GO:0006952 IEA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IEA
    leptin-mediated signaling pathway GO:0033210 IEA
    regulation of cell population proliferation GO:0042127 IEA
    response to peptide hormone GO:0043434 IEA
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IEA
 Experiment description of studies that identified STAT3 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STAT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here