Gene description for STX4
Gene name syntaxin 4
Gene symbol STX4
Other names/aliases -
Species Bos taurus
 Database cross references - STX4
ExoCarta ExoCarta_508675
Entrez Gene 508675
UniProt Q3SWZ3  
 STX4 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for STX4
Molecular Function
    protein binding GO:0005515 IPI
    SNARE binding GO:0000149 IBA
    SNAP receptor activity GO:0005484 IBA
    sphingomyelin phosphodiesterase activator activity GO:0016230 IEA
Biological Process
    exocytosis GO:0006887 IBA
    positive regulation of eosinophil degranulation GO:0043311 IEA
    synaptic vesicle fusion to presynaptic membrane GO:0031629 IBA
    positive regulation of cell proliferation GO:0008284 IEA
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of establishment of protein localization to plasma membrane GO:0090004 IEA
    intracellular protein transport GO:0006886 IBA
    response to hydroperoxide GO:0033194 IEA
    regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 IEA
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA
    positive regulation of protein localization to cell surface GO:2000010 IEA
    long-term synaptic potentiation GO:0060291 IEA
    positive regulation of chemotaxis GO:0050921 IEA
    positive regulation of immunoglobulin secretion GO:0051024 IEA
    positive regulation of cell adhesion GO:0045785 IEA
    positive regulation of catalytic activity GO:0043085 IEA
    SNARE complex assembly GO:0035493 IEA
    vesicle docking GO:0048278 IBA
Subcellular Localization
    dendritic spine GO:0043197 IEA
    synaptic vesicle GO:0008021 IBA
    basolateral plasma membrane GO:0016323 IEA
    lateral loop GO:0043219 IEA
    specific granule GO:0042581 IEA
    plasma membrane GO:0005886 IBA
    cell surface GO:0009986 IEA
    caveola GO:0005901 IDA
    integral component of membrane GO:0016021 IBA
    myelin sheath adaxonal region GO:0035749 IEA
    endomembrane system GO:0012505 IBA
    SNARE complex GO:0031201 ISS
    perinuclear region of cytoplasm GO:0048471 IEA
    extracellular exosome GO:0070062 IEA
    extracellular space GO:0005615 IEA
    lamellipodium GO:0030027 IEA
    trans-Golgi network GO:0005802 IEA
    endosome GO:0005768 IEA
 Experiment description of studies that identified STX4 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STX4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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