Gene description for PFKL
Gene name phosphofructokinase, liver
Gene symbol PFKL
Other names/aliases ATP-PFK
PFK-L
Species Bos taurus
 Database cross references - PFKL
ExoCarta ExoCarta_508683
Entrez Gene 508683
UniProt A1A4J1  
 PFKL identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PFKL
Molecular Function
    ATP binding GO:0005524 IEA
    kinase binding GO:0019900 IEA
    identical protein binding GO:0042802 IEA
    metal ion binding GO:0046872 IEA
    fructose binding GO:0070061 IEA
    fructose-6-phosphate binding GO:0070095 IEA
    6-phosphofructokinase activity GO:0003872 ISS
Biological Process
    fructose 1,6-bisphosphate metabolic process GO:0030388 ISS
    glycolytic process GO:0006096 ISS
    carbohydrate phosphorylation GO:0046835 ISS
    fructose 6-phosphate metabolic process GO:0006002 IEA
    protein oligomerization GO:0051259 IEA
    response to glucose GO:0009749 ISS
    negative regulation of insulin secretion GO:0046676 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    6-phosphofructokinase complex GO:0005945 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PFKL in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PFKL
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PFKL is involved
PathwayEvidenceSource
Glycolysis IEA Reactome





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