Gene description for DHFR
Gene name dihydrofolate reductase
Gene symbol DHFR
Other names/aliases -
Species Bos taurus
 Database cross references - DHFR
ExoCarta ExoCarta_508809
Entrez Gene 508809
UniProt P00376  
 DHFR identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for DHFR
Molecular Function
    NADP binding GO:0050661 IEA
    mRNA binding GO:0003729 ISS
    drug binding GO:0008144 ISS
    dihydrofolate reductase activity GO:0004146 ISS
Biological Process
    one-carbon metabolic process GO:0006730 IEA
    tetrahydrofolate metabolic process GO:0046653 ISS
    oxidation-reduction process GO:0055114 IEA
    response to methotrexate GO:0031427 IEA
    tetrahydrofolate biosynthetic process GO:0046654 IEA
    nucleotide biosynthetic process GO:0009165 IEA
    glycine biosynthetic process GO:0006545 IEA
 Experiment description of studies that identified DHFR in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DHFR
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here