Gene description for C1s1
Gene name complement component 1, s subcomponent 1
Gene symbol C1s1
Other names/aliases AA959438
Species Mus musculus
 Database cross references - C1s1
ExoCarta ExoCarta_50908
Entrez Gene 50908
UniProt Q8CG14  
 C1s1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for C1s1
Molecular Function
    serine-type endopeptidase activity GO:0004252 ISO
    serine-type peptidase activity GO:0008236 IEA
    hydrolase activity GO:0016787 IEA
    metal ion binding GO:0046872 IEA
    peptidase activity GO:0008233 IEA
    identical protein binding GO:0042802 ISO
    calcium ion binding GO:0005509 IEA
Biological Process
    innate immune response GO:0045087 IEA
    complement activation GO:0006956 IEA
    immune system process GO:0002376 IEA
    proteolysis GO:0006508 ISO
    complement activation, classical pathway GO:0006958 IEA
Subcellular Localization
    extracellular region GO:0005576 ISO
    blood microparticle GO:0072562 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified C1s1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C1s1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which C1s1 is involved
No pathways found

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