Gene description for PKN1
Gene name protein kinase N1
Gene symbol PKN1
Other names/aliases -
Species Bos taurus
 Database cross references - PKN1
ExoCarta ExoCarta_509080
Entrez Gene 509080
UniProt A1A4I4  
 PKN1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PKN1
Molecular Function
    histone deacetylase binding GO:0042826 ISS
    histone binding GO:0042393 ISS
    GTP-Rho binding GO:0017049 ISS
    ATP binding GO:0005524 IEA
    protein kinase C activity GO:0004697 IEA
    Rac GTPase binding GO:0048365 ISS
    protein kinase C binding GO:0005080 IEA
    androgen receptor binding GO:0050681 ISS
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 ISS
    chromatin binding GO:0003682 ISS
    histone kinase activity (H3-T11 specific) GO:0035402 ISS
    protein serine/threonine kinase activity GO:0004674 ISS
Biological Process
    protein phosphorylation GO:0006468 ISS
    transcription, DNA-templated GO:0006351 IEA
    histone H3-T11 phosphorylation GO:0035407 ISS
    regulation of cell motility GO:2000145 ISS
    hyperosmotic response GO:0006972 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 ISS
    epithelial cell migration GO:0010631 ISS
    signal transduction GO:0007165 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    endosome GO:0005768 ISS
    plasma membrane GO:0005886 IEA
    midbody GO:0030496 ISS
    cleavage furrow GO:0032154 ISS
    nucleus GO:0005634 ISS
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
 Experiment description of studies that identified PKN1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PKN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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