Gene description for C1ra
Gene name complement component 1, r subcomponent A
Gene symbol C1ra
Other names/aliases AI132558
C1r
mC1rA
Species Mus musculus
 Database cross references - C1ra
ExoCarta ExoCarta_50909
Vesiclepedia VP_50909
Entrez Gene 50909
UniProt Q8CG16  
 C1ra identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for C1ra
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type endopeptidase activity GO:0004252 ISO
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    identical protein binding GO:0042802 ISO
    molecular sequestering activity GO:0140313 ISO
Biological Process
    proteolysis GO:0006508 IEA
    complement activation, classical pathway GO:0006958 IEA
    zymogen activation GO:0031638 IBA
    zymogen activation GO:0031638 ISO
    innate immune response GO:0045087 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    blood microparticle GO:0072562 IBA
 Experiment description of studies that identified C1ra in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C1ra
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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