Gene description for C1ra
Gene name complement component 1, r subcomponent A
Gene symbol C1ra
Other names/aliases AI132558
C1r
mC1rA
Species Mus musculus
 Database cross references - C1ra
ExoCarta ExoCarta_50909
Entrez Gene 50909
UniProt Q8CG16  
 C1ra identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for C1ra
Molecular Function
    serine-type peptidase activity GO:0008236 IEA
    hydrolase activity GO:0016787 IEA
    calcium ion binding GO:0005509 IEA
    peptidase activity GO:0008233 IEA
    serine-type endopeptidase activity GO:0004252 ISO
Biological Process
    immune system process GO:0002376 IEA
    complement activation GO:0006956 IEA
    complement activation, classical pathway GO:0006958 IEA
    proteolysis GO:0006508 ISO
    innate immune response GO:0045087 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    blood microparticle GO:0072562 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified C1ra in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C1ra
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which C1ra is involved
PathwayEvidenceSource
Classical antibody-mediated complement activation IEA Reactome
Initial triggering of complement IEA Reactome





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