Gene description for C1ra
Gene name complement component 1, r subcomponent A
Gene symbol C1ra
Other names/aliases AI132558
Species Mus musculus
 Database cross references - C1ra
ExoCarta ExoCarta_50909
Entrez Gene 50909
UniProt Q8CG16  
 C1ra identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for C1ra
Molecular Function
    serine-type peptidase activity GO:0008236 IEA
    hydrolase activity GO:0016787 IEA
    calcium ion binding GO:0005509 IEA
    peptidase activity GO:0008233 IEA
    serine-type endopeptidase activity GO:0004252 ISO
Biological Process
    immune system process GO:0002376 IEA
    complement activation GO:0006956 IEA
    complement activation, classical pathway GO:0006958 IEA
    proteolysis GO:0006508 ISO
    innate immune response GO:0045087 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    blood microparticle GO:0072562 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified C1ra in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C1ra
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which C1ra is involved
Classical antibody-mediated complement activation IEA Reactome
Initial triggering of complement IEA Reactome

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