Gene description for ACE2
Gene name angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Gene symbol ACE2
Other names/aliases -
Species Bos taurus
 Database cross references - ACE2
ExoCarta ExoCarta_509235
Entrez Gene 509235
UniProt Q58DD0  
 ACE2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ACE2
Molecular Function
    virus receptor activity GO:0001618 ISS
    metal ion binding GO:0046872 IEA
    glycoprotein binding GO:0001948 IEA
    endopeptidase activity GO:0004175 IEA
    metallopeptidase activity GO:0008237 IEA
    peptidyl-dipeptidase activity GO:0008241 IEA
    carboxypeptidase activity GO:0004180 IEA
Biological Process
    receptor biosynthetic process GO:0032800 IEA
    proteolysis GO:0006508 IEA
    response to virus GO:0009615 IEA
    receptor-mediated virion attachment to host cell GO:0046813 IEA
    viral entry into host cell GO:0046718 ISS
    angiotensin-mediated drinking behavior GO:0003051 IEA
Subcellular Localization
    plasma membrane GO:0005886 ISS
    cytoplasm GO:0005737 IEA
    cell surface GO:0009986 ISS
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified ACE2 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACE2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ACE2 is involved
PathwayEvidenceSource
Metabolism of Angiotensinogen to Angiotensins IEA Reactome





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