Gene description for CIB1
Gene name calcium and integrin binding 1 (calmyrin)
Gene symbol CIB1
Other names/aliases -
Species Bos taurus
 Database cross references - CIB1
ExoCarta ExoCarta_510141
Entrez Gene 510141
UniProt Q17QE5  
 CIB1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CIB1
Molecular Function
    calcium ion binding GO:0005509 IEA
    Ras GTPase binding GO:0017016 IEA
    protein anchor GO:0043495 IEA
    ion channel binding GO:0044325 IEA
Biological Process
    negative regulation of apoptotic process GO:0043066 ISS
    response to ischemia GO:0002931 ISS
    positive regulation of cell adhesion mediated by integrin GO:0033630 ISS
    cellular response to growth factor stimulus GO:0071363 ISS
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISS
    cellular response to DNA damage stimulus GO:0006974 IEA
    negative regulation of cell proliferation GO:0008285 ISS
    negative regulation of protein kinase B signaling GO:0051898 ISS
    negative regulation of megakaryocyte differentiation GO:0045653 ISS
    positive regulation of cell-matrix adhesion GO:0001954 ISS
    positive regulation of metalloenzyme activity GO:0048554 ISS
    positive regulation of cell migration GO:0030335 ISS
    positive regulation of establishment of protein localization to plasma membrane GO:0090004 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS
    thrombopoietin-mediated signaling pathway GO:0038163 ISS
    cellular response to tumor necrosis factor GO:0071356 ISS
    endomitotic cell cycle GO:0007113 ISS
    apoptotic process GO:0006915 IEA
    negative regulation of protein phosphorylation GO:0001933 ISS
    spermatid development GO:0007286 ISS
    angiogenesis GO:0001525 IEA
    cell adhesion GO:0007155 IEA
    positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISS
    positive regulation of calcineurin-NFAT signaling cascade GO:0070886 IEA
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISS
    positive regulation of male germ cell proliferation GO:2000256 ISS
    positive regulation of protein phosphorylation GO:0001934 ISS
    positive regulation of cell proliferation GO:0008284 ISS
    positive regulation of cell growth GO:0030307 ISS
    cytoplasmic microtubule organization GO:0031122 ISS
    platelet formation GO:0030220 ISS
    regulation of cell division GO:0051302 ISS
    cellular response to nerve growth factor stimulus GO:1990090 ISS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS
    positive regulation of protein targeting to membrane GO:0090314 ISS
    regulation of cell proliferation GO:0042127 ISS
    cell division GO:0051301 IEA
    negative regulation of microtubule depolymerization GO:0007026 ISS
    negative regulation of neuron projection development GO:0010977 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISS
    neuronal cell body GO:0043025 ISS
    sarcolemma GO:0042383 IEA
    plasma membrane GO:0005886 ISS
    cell periphery GO:0071944 ISS
    growth cone GO:0030426 ISS
    extracellular exosome GO:0070062 IEA
    endoplasmic reticulum GO:0005783 IEA
    lamellipodium GO:0030027 ISS
    centrosome GO:0005813 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
    nucleoplasm GO:0005654 IEA
    neuron projection GO:0043005 ISS
    ruffle membrane GO:0032587 IEA
    apical plasma membrane GO:0016324 IEA
    filopodium tip GO:0032433 ISS
    nucleus GO:0005634 ISS
 Experiment description of studies that identified CIB1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CIB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CIB1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here