Gene description for DDX1
Gene name DEAD (Asp-Glu-Ala-Asp) box helicase 1
Gene symbol DDX1
Other names/aliases -
Species Bos taurus
 Database cross references - DDX1
ExoCarta ExoCarta_510816
Entrez Gene 510816
UniProt Q0IIK5  
 DDX1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for DDX1
Molecular Function
    ATP-dependent helicase activity GO:0008026 ISS
    double-stranded RNA binding GO:0003725 IEA
    DNA/RNA helicase activity GO:0033677 ISS
    poly(A) binding GO:0008143 ISS
    nuclease activity GO:0004518 ISS
    ATP binding GO:0005524 IEA
    ATP-dependent RNA helicase activity GO:0004004 IBA
    transcription cofactor activity GO:0003712 ISS
    poly(A) RNA binding GO:0044822 IEA
    exonuclease activity GO:0004527 IEA
    chromatin binding GO:0003682 ISS
    DNA binding GO:0003677 IEA
Biological Process
    multicellular organismal development GO:0007275 IEA
    mRNA processing GO:0006397 IEA
    nucleic acid phosphodiester bond hydrolysis GO:0090305 ISS
    response to exogenous dsRNA GO:0043330 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    RNA secondary structure unwinding GO:0010501 IBA
    double-strand break repair GO:0006302 ISS
    response to virus GO:0009615 IEA
    transcription, DNA-templated GO:0006351 IEA
    DNA duplex unwinding GO:0032508 ISS
    tRNA splicing, via endonucleolytic cleavage and ligation GO:0006388 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISS
    cytoplasmic stress granule GO:0010494 ISS
    membrane GO:0016020 IEA
    cleavage body GO:0071920 ISS
    nucleus GO:0005634 ISS
    tRNA-splicing ligase complex GO:0072669 ISS
 Experiment description of studies that identified DDX1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DDX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DDX1 is involved
No pathways found





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