Gene description for ACLY
Gene name ATP citrate lyase
Gene symbol ACLY
Other names/aliases -
Species Bos taurus
 Database cross references - ACLY
ExoCarta ExoCarta_511135
Entrez Gene 511135
UniProt Q32PF2  
 ACLY identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ACLY
Molecular Function
    cofactor binding GO:0048037 IEA
    ATP citrate synthase activity GO:0003878 IEA
    ATP binding GO:0005524 IEA
    succinate-CoA ligase (ADP-forming) activity GO:0004775 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    cellular carbohydrate metabolic process GO:0044262 IEA
    lipid biosynthetic process GO:0008610 ISS
Subcellular Localization
    mitochondrion GO:0005739 IEA
    extracellular exosome GO:0070062 IEA
    nucleoplasm GO:0005654 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified ACLY in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACLY
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ACLY is involved
PathwayEvidenceSource
ChREBP activates metabolic gene expression IEA Reactome
Fatty Acyl-CoA Biosynthesis IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here