Gene description for PARK7
Gene name parkinson protein 7
Gene symbol PARK7
Other names/aliases DJ-1
Species Bos taurus
 Database cross references - PARK7
ExoCarta ExoCarta_511268
Entrez Gene 511268
UniProt Q5E946  
 PARK7 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PARK7
Molecular Function
    kinase binding GO:0019900 IEA
    small protein activating enzyme binding GO:0044388 IEA
    cytokine binding GO:0019955 IEA
    tyrosine 3-monooxygenase activator activity GO:0036470 IEA
    copper ion binding GO:0005507 ISS
    L-dopa decarboxylase activator activity GO:0036478 IEA
    cupric ion binding GO:1903135 IEA
    mercury ion binding GO:0045340 ISS
    cuprous ion binding GO:1903136 IEA
    androgen receptor binding GO:0050681 IEA
    mRNA binding GO:0003729 ISS
    transcription coactivator activity GO:0003713 IEA
    protein homodimerization activity GO:0042803 ISS
    glyoxalase (glycolic acid-forming) activity GO:1990422 IEA
    peroxiredoxin activity GO:0051920 IEA
    superoxide dismutase copper chaperone activity GO:0016532 IEA
    peptidase activity GO:0008233 ISS
    glyoxalase III activity GO:0019172 IEA
    repressing transcription factor binding GO:0070491 IEA
    ubiquitin-specific protease binding GO:1990381 IEA
    scaffold protein binding GO:0097110 IEA
    ubiquitin-like protein conjugating enzyme binding GO:0044390 IEA
Biological Process
    positive regulation of tyrosine 3-monooxygenase activity GO:1903178 IEA
    regulation of mitochondrial membrane potential GO:0051881 IEA
    membrane depolarization GO:0051899 IEA
    inflammatory response GO:0006954 IEA
    dopamine uptake involved in synaptic transmission GO:0051583 IEA
    positive regulation of androgen receptor activity GO:2000825 IEA
    positive regulation of L-dopa biosynthetic process GO:1903197 IEA
    positive regulation of interleukin-8 production GO:0032757 IEA
    cellular response to glyoxal GO:0036471 IEA
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IEA
    negative regulation of protein binding GO:0032091 ISS
    regulation of neuron apoptotic process GO:0043523 ISS
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA
    autophagy GO:0006914 IEA
    protein deglycosylation GO:0006517 ISS
    positive regulation of protein localization to nucleus GO:1900182 IEA
    negative regulation of TRAIL-activated apoptotic signaling pathway GO:1903122 IEA
    enzyme active site formation via L-cysteine sulfinic acid GO:0018323 IEA
    single fertilization GO:0007338 IEA
    glycolate biosynthetic process GO:0046295 IEA
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway GO:1903384 IEA
    negative regulation of protein kinase activity GO:0006469 IEA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001268 IEA
    glyoxal catabolic process GO:1903190 IEA
    cellular response to oxidative stress GO:0034599 ISS
    detoxification of mercury ion GO:0050787 ISS
    positive regulation of superoxide dismutase activity GO:1901671 IEA
    methylglyoxal catabolic process to D-lactate GO:0019243 IEA
    negative regulation of gene expression GO:0010629 IEA
    positive regulation of transcription regulatory region DNA binding GO:2000679 IEA
    positive regulation of pyrroline-5-carboxylate reductase activity GO:1903168 IEA
    positive regulation of oxidative phosphorylation uncoupler activity GO:2000277 ISS
    cellular response to hydrogen peroxide GO:0070301 ISS
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IEA
    negative regulation of cell death GO:0060548 ISS
    negative regulation of protein acetylation GO:1901984 IEA
    negative regulation of protein export from nucleus GO:0046826 IEA
    protein stabilization GO:0050821 ISS
    negative regulation of protein sumoylation GO:0033234 IEA
    detoxification of copper ion GO:0010273 ISS
    positive regulation of protein homodimerization activity GO:0090073 IEA
    adult locomotory behavior GO:0008344 IEA
    mitochondrion organization GO:0007005 ISS
    membrane hyperpolarization GO:0060081 IEA
    negative regulation of ubiquitin-specific protease activity GO:2000157 IEA
    proteolysis GO:0006508 IEA
    positive regulation of L-dopa decarboxylase activity GO:1903200 IEA
    negative regulation of protein K48-linked deubiquitination GO:1903094 IEA
    regulation of inflammatory response GO:0050727 ISS
    positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 IEA
    lactate biosynthetic process GO:0019249 IEA
    hydrogen peroxide metabolic process GO:0042743 IEA
    negative regulation of ubiquitin-protein transferase activity GO:0051444 IEA
Subcellular Localization
    PML body GO:0016605 IEA
    cell body GO:0044297 IEA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IEA
    nucleus GO:0005634 ISS
    mitochondrial intermembrane space GO:0005758 IEA
    mitochondrial respiratory chain complex I GO:0005747 IEA
    membrane raft GO:0045121 IEA
    plasma membrane GO:0005886 IEA
    cytosol GO:0005829 ISS
    mitochondrial matrix GO:0005759 IEA
    chromatin GO:0000785 IEA
    mitochondrion GO:0005739 ISS
    neuron projection GO:0043005 IEA
 Experiment description of studies that identified PARK7 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PARK7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PARK7 is involved
No pathways found

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