Gene description for DDB1
Gene name damage-specific DNA binding protein 1, 127kDa
Gene symbol DDB1
Other names/aliases -
Species Bos taurus
 Database cross references - DDB1
ExoCarta ExoCarta_511951
Entrez Gene 511951
UniProt A1A4K3  
 DDB1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for DDB1
Molecular Function
    damaged DNA binding GO:0003684 IBA
Biological Process
    positive regulation by virus of viral protein levels in host cell GO:0046726 IEA
    positive regulation of viral genome replication GO:0045070 IEA
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    regulation of mitotic cell cycle phase transition GO:1901990 IEA
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IEA
    interaction with symbiont GO:0051702 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    nucleotide-excision repair GO:0006289 IBA
    UV-damage excision repair GO:0070914 IEA
    histone H2A monoubiquitination GO:0035518 IEA
    positive regulation of viral release from host cell GO:1902188 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    Cul4A-RING E3 ubiquitin ligase complex GO:0031464 ISS
    extracellular exosome GO:0070062 IEA
    Cul4B-RING E3 ubiquitin ligase complex GO:0031465 ISS
    Cul4-RING E3 ubiquitin ligase complex GO:0080008 ISS
    nucleoplasm GO:0005654 IEA
    extracellular space GO:0005615 IEA
    cullin-RING ubiquitin ligase complex GO:0031461 IBA
    nucleus GO:0005634 ISS
 Experiment description of studies that identified DDB1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DDB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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