Gene description for IMPDH2
Gene name IMP (inosine 5'-monophosphate) dehydrogenase 2
Gene symbol IMPDH2
Other names/aliases -
Species Bos taurus
 Database cross references - IMPDH2
ExoCarta ExoCarta_511969
Entrez Gene 511969
UniProt Q3SWY3  
 IMPDH2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for IMPDH2
Molecular Function
    IMP dehydrogenase activity GO:0003938 IEA
    nucleotide binding GO:0000166 ISS
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    lymphocyte proliferation GO:0046651 IEA
    GMP biosynthetic process GO:0006177 IEA
    oxidation-reduction process GO:0055114 IEA
    cellular response to interleukin-4 GO:0071353 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    peroxisomal membrane GO:0005778 IEA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified IMPDH2 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IMPDH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IMPDH2 is involved
PathwayEvidenceSource
Purine ribonucleoside monophosphate biosynthesis IEA Reactome





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