Gene description for CHP1
Gene name calcineurin-like EF-hand protein 1
Gene symbol CHP1
Other names/aliases CHP
Species Bos taurus
 Database cross references - CHP1
ExoCarta ExoCarta_512662
Entrez Gene 512662
UniProt Q3SYS6  
 CHP1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CHP1
Molecular Function
    calcium ion binding GO:0005509 ISS
    calcium-dependent protein binding GO:0048306 ISS
    microtubule binding GO:0008017 ISS
    protein kinase inhibitor activity GO:0004860 IEA
    kinase binding GO:0019900 ISS
    transporter activity GO:0005215 ISS
Biological Process
    microtubule bundle formation GO:0001578 ISS
    negative regulation of protein ubiquitination GO:0031397 ISS
    positive regulation of protein transport GO:0051222 ISS
    positive regulation of protein targeting to membrane GO:0090314 ISS
    protein stabilization GO:0050821 ISS
    membrane docking GO:0022406 ISS
    negative regulation of protein autophosphorylation GO:0031953 ISS
    positive regulation of sodium:proton antiporter activity GO:0032417 ISS
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISS
    cellular response to acidic pH GO:0071468 ISS
    membrane organization GO:0061024 ISS
    protein export from nucleus GO:0006611 ISS
    negative regulation of protein import into nucleus GO:0042308 ISS
    negative regulation of protein phosphorylation GO:0001933 ISS
    cytoplasmic microtubule organization GO:0031122 ISS
    positive regulation of protein glycosylation GO:0060050 ISS
    negative regulation of phosphatase activity GO:0010923 ISS
    regulation of intracellular pH GO:0051453 ISS
    membrane fusion GO:0061025 ISS
    negative regulation of protein kinase activity GO:0006469 ISS
    negative regulation of calcineurin-NFAT signaling cascade GO:0070885 ISS
    regulation of neuron death GO:1901214 IEA
Subcellular Localization
    Golgi membrane GO:0000139 ISS
    endoplasmic reticulum GO:0005783 ISS
    plasma membrane GO:0005886 ISS
    extracellular exosome GO:0070062 IEA
    focal adhesion GO:0005925 IEA
    microtubule cytoskeleton GO:0015630 ISS
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    cytoplasm GO:0005737 ISS
    nucleus GO:0005634 ISS
    transport vesicle GO:0030133 ISS
 Experiment description of studies that identified CHP1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CHP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CHP1 is involved
PathwayEvidenceSource
Hyaluronan uptake and degradation IEA Reactome





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