Gene description for NOTCH2
Gene name notch 2
Gene symbol NOTCH2
Other names/aliases -
Species Bos taurus
 Database cross references - NOTCH2
ExoCarta ExoCarta_513730
Vesiclepedia VP_513730
Entrez Gene 513730
 NOTCH2 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for NOTCH2
Molecular Function
    Notch binding GO:0005112 IEA
    calcium ion binding GO:0005509 IEA
    signaling receptor activity GO:0038023 IEA
Biological Process
    regulation of DNA-templated transcription GO:0006355 IEA
    apoptotic process GO:0006915 IEA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IEA
    Notch signaling pathway GO:0007219 IEA
    multicellular organism development GO:0007275 IEA
    cell differentiation GO:0030154 IEA
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 IEA
    regulation of developmental process GO:0050793 IEA
    cellular response to tumor cell GO:0071228 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    receptor complex GO:0043235 IEA
 Experiment description of studies that identified NOTCH2 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NOTCH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NOTCH2 is involved
No pathways found





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