Gene description for A2M
Gene name alpha-2-macroglobulin
Gene symbol A2M
Other names/aliases -
Species Bos taurus
 Database cross references - A2M
ExoCarta ExoCarta_513856
Entrez Gene 513856
UniProt Q7SIH1  
 A2M identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for A2M
Molecular Function
    protease binding GO:0002020 IEA
    interleukin-1 binding GO:0019966 IEA
    tumor necrosis factor binding GO:0043120 IEA
    receptor binding GO:0005102 IEA
    interleukin-8 binding GO:0019959 IEA
    calcium-dependent protein binding GO:0048306 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
Biological Process
    negative regulation of complement activation, lectin pathway GO:0001869 IEA
    negative regulation of endopeptidase activity GO:0010951 IEA
    stem cell differentiation GO:0048863 IEA
Subcellular Localization
    blood microparticle GO:0072562 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified A2M in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for A2M
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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