Gene description for A2M
Gene name alpha-2-macroglobulin
Gene symbol A2M
Other names/aliases -
Species Bos taurus
 Database cross references - A2M
ExoCarta ExoCarta_513856
Entrez Gene 513856
UniProt Q7SIH1  
 A2M identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for A2M
Molecular Function
    protease binding GO:0002020 IEA
    interleukin-1 binding GO:0019966 IEA
    tumor necrosis factor binding GO:0043120 IEA
    receptor binding GO:0005102 IEA
    interleukin-8 binding GO:0019959 IEA
    calcium-dependent protein binding GO:0048306 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
Biological Process
    negative regulation of complement activation, lectin pathway GO:0001869 IEA
    negative regulation of endopeptidase activity GO:0010951 IEA
    stem cell differentiation GO:0048863 IEA
Subcellular Localization
    blood microparticle GO:0072562 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified A2M in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for A2M
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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