Gene description for CFB
Gene name complement factor B
Gene symbol CFB
Other names/aliases BF
Species Bos taurus
 Database cross references - CFB
ExoCarta ExoCarta_514076
Entrez Gene 514076
UniProt P81187  
 CFB identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for CFB
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
Biological Process
    complement activation, alternative pathway GO:0006957 IEA
    proteolysis GO:0006508 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified CFB in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CFB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CFB is involved
PathwayEvidenceSource
Activation of C3 and C5 IEA Reactome
Alternative complement activation IEA Reactome
Regulation of Complement cascade IEA Reactome





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