Gene description for PDXK
Gene name pyridoxal (pyridoxine, vitamin B6) kinase
Gene symbol PDXK
Other names/aliases -
Species Bos taurus
 Database cross references - PDXK
ExoCarta ExoCarta_514168
Entrez Gene 514168
UniProt Q0II59  
 PDXK identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PDXK
Molecular Function
    zinc ion binding GO:0008270 IEA
    sodium ion binding GO:0031402 IEA
    lithium ion binding GO:0031403 IEA
    ATP binding GO:0005524 IEA
    pyridoxal phosphate binding GO:0030170 IEA
    potassium ion binding GO:0030955 IEA
    pyridoxal kinase activity GO:0008478 IEA
    magnesium ion binding GO:0000287 IEA
    protein homodimerization activity GO:0042803 IEA
Biological Process
    pyridoxal 5'-phosphate salvage GO:0009443 IEA
    phosphorylation GO:0016310 IEA
    cell proliferation GO:0008283 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    cytosol GO:0005829 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PDXK in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PDXK
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PDXK is involved
PathwayEvidenceSource
Vitamins B6 activation to pyridoxal phosphate IEA Reactome





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