Gene description for PARL
Gene name presenilin associated, rhomboid-like
Gene symbol PARL
Other names/aliases PSARL
Species Bos taurus
 Database cross references - PARL
ExoCarta ExoCarta_514191
Entrez Gene 514191
UniProt Q2KHV4  
 PARL identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PARL
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
Biological Process
    regulation of reactive oxygen species metabolic process GO:2000377 IEA
    negative regulation of release of cytochrome c from mitochondria GO:0090201 IEA
    protein processing GO:0016485 IBA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IEA
Subcellular Localization
    mitochondrial inner membrane GO:0005743 IBA
    nucleus GO:0005634 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified PARL in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PARL
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PARL is involved
No pathways found





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