Gene description for PPP2R4
Gene name protein phosphatase 2A activator, regulatory subunit 4
Gene symbol PPP2R4
Other names/aliases -
Species Bos taurus
 Database cross references - PPP2R4
ExoCarta ExoCarta_514460
Entrez Gene 514460
UniProt Q2KJ44  
 PPP2R4 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPP2R4
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    receptor binding GO:0005102 IEA
    protein tyrosine phosphatase activator activity GO:0008160 IBA
    protein phosphatase type 2A regulator activity GO:0008601 IBA
    protein phosphatase 2A binding GO:0051721 IEA
    ATP binding GO:0005524 IEA
    ATPase activity GO:0016887 IEA
    protein homodimerization activity GO:0042803 IEA
Biological Process
    negative regulation of protein dephosphorylation GO:0035308 IEA
    regulation of protein phosphatase type 2A activity GO:0034047 IBA
    positive regulation of apoptotic process GO:0043065 IEA
    positive regulation of phosphoprotein phosphatase activity GO:0032516 IEA
    negative regulation of phosphoprotein phosphatase activity GO:0032515 IEA
    protein peptidyl-prolyl isomerization GO:0000413 IEA
    positive regulation of protein dephosphorylation GO:0035307 IEA
    mitotic spindle organization in nucleus GO:0030472 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    extracellular exosome GO:0070062 IEA
    cytoplasm GO:0005737 IBA
    protein phosphatase type 2A complex GO:0000159 IBA
    nucleus GO:0005634 IBA
    calcium channel complex GO:0034704 IEA
 Experiment description of studies that identified PPP2R4 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2R4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPP2R4 is involved
No pathways found





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