Gene description for SYK
Gene name spleen tyrosine kinase
Gene symbol SYK
Other names/aliases -
Species Bos taurus
 Database cross references - SYK
ExoCarta ExoCarta_515515
Vesiclepedia VP_515515
Entrez Gene 515515
 SYK identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SYK
Molecular Function
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA
    signaling receptor binding GO:0005102 IEA
    ATP binding GO:0005524 IEA
Biological Process
    adaptive immune response GO:0002250 IEA
    macrophage activation involved in immune response GO:0002281 IEA
    neutrophil activation involved in immune response GO:0002283 IEA
    protein phosphorylation GO:0006468 IEA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    cell differentiation GO:0030154 IEA
    positive regulation of cell adhesion mediated by integrin GO:0033630 IEA
    intracellular signal transduction GO:0035556 IEA
    positive regulation of mast cell degranulation GO:0043306 IEA
    innate immune response GO:0045087 IEA
    positive regulation of B cell differentiation GO:0045579 IEA
    positive regulation of alpha-beta T cell proliferation GO:0046641 IEA
    B cell receptor signaling pathway GO:0050853 IEA
    regulation of platelet aggregation GO:0090330 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IEA
 Experiment description of studies that identified SYK in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SYK
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SYK is involved
No pathways found





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