Gene description for CLIC1
Gene name chloride intracellular channel 1
Gene symbol CLIC1
Other names/aliases -
Species Bos taurus
 Database cross references - CLIC1
ExoCarta ExoCarta_515646
Entrez Gene 515646
UniProt Q5E9B7  
 CLIC1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for CLIC1
Molecular Function
    chloride channel activity GO:0005254 IEA
    voltage-gated ion channel activity GO:0005244 IEA
Biological Process
    platelet aggregation GO:0070527 IEA
    chloride transmembrane transport GO:1902476 IEA
    regulation of mitochondrial membrane potential GO:0051881 IEA
    positive regulation of osteoblast differentiation GO:0045669 IEA
    regulation of cell cycle GO:0051726 IEA
    regulation of ion transmembrane transport GO:0034765 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 IEA
    chloride channel complex GO:0034707 IEA
    blood microparticle GO:0072562 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    mitochondrion GO:0005739 IEA
    nuclear membrane GO:0031965 IEA
 Experiment description of studies that identified CLIC1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLIC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CLIC1 is involved
No pathways found





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