Gene description for UPB1
Gene name ureidopropionase, beta
Gene symbol UPB1
Other names/aliases BUP1
Species Homo sapiens
 Database cross references - UPB1
ExoCarta ExoCarta_51733
Vesiclepedia VP_51733
Entrez Gene 51733
HGNC 16297
MIM 606673
UniProt Q9UBR1  
 UPB1 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for UPB1
Molecular Function
    beta-ureidopropionase activity GO:0003837 IBA
    beta-ureidopropionase activity GO:0003837 IDA
    zinc ion binding GO:0008270 IDA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    in utero embryonic development GO:0001701 IEA
    liver development GO:0001889 IEA
    CMP catabolic process GO:0006248 IEA
    dCMP catabolic process GO:0006249 IEA
    beta-alanine biosynthetic process via 3-ureidopropionate GO:0033396 IBA
    beta-alanine biosynthetic process via 3-ureidopropionate GO:0033396 IDA
    UMP catabolic process GO:0046050 IEA
    dUMP catabolic process GO:0046079 IEA
    pyrimidine nucleoside catabolic process GO:0046135 IMP
    protein homooligomerization GO:0051260 IDA
    protein homotetramerization GO:0051289 IDA
Subcellular Localization
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified UPB1 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for UPB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARMT1 79624
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which UPB1 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of nucleotides TAS Reactome
Nucleotide catabolism TAS Reactome
Pyrimidine catabolism TAS Reactome





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