Gene description for UPB1
Gene name ureidopropionase, beta
Gene symbol UPB1
Other names/aliases BUP1
Species Homo sapiens
 Database cross references - UPB1
ExoCarta ExoCarta_51733
Entrez Gene 51733
HGNC 16297
MIM 606673
UniProt Q9UBR1  
 UPB1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for UPB1
Molecular Function
    metal ion binding GO:0046872 IEA
    beta-ureidopropionase activity GO:0003837 EXP
Biological Process
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    pyrimidine nucleobase metabolic process GO:0006206 TAS
    beta-alanine biosynthetic process GO:0019483 IEA
    small molecule metabolic process GO:0044281 TAS
    pyrimidine nucleoside catabolic process GO:0046135 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified UPB1 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for UPB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UPB1 is involved
PathwayEvidenceSource
Pyrimidine catabolism TAS Reactome





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