Gene description for ATP8B1
Gene name ATPase, aminophospholipid transporter, class I, type 8B, member 1
Gene symbol ATP8B1
Other names/aliases ATPIC
BRIC
FIC1
ICP1
PFIC
PFIC1
Species Homo sapiens
 Database cross references - ATP8B1
ExoCarta ExoCarta_5205
Entrez Gene 5205
HGNC 3706
MIM 602397
UniProt O43520  
 ATP8B1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ATP8B1
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    magnesium ion binding GO:0000287 IEA
    cardiolipin binding GO:1901612 IEA
    phospholipid-translocating ATPase activity GO:0004012 TAS
Biological Process
    sensory perception of sound GO:0007605 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IMP
    bile acid and bile salt transport GO:0015721 NAS
    regulation of microvillus assembly GO:0032534 IMP
    ion transmembrane transport GO:0034220 TAS
    drug transmembrane transport GO:0006855 IDA
    vestibulocochlear nerve formation GO:0021650 IEA
    inner ear receptor cell development GO:0060119 IEA
    Golgi organization GO:0007030 IBA
    transmembrane transport GO:0055085 TAS
    bile acid metabolic process GO:0008206 IEA
    phospholipid translocation GO:0045332 NAS
Subcellular Localization
    brush border membrane GO:0031526 IEA
    integral component of plasma membrane GO:0005887 NAS
    plasma membrane GO:0005886 TAS
    Golgi apparatus GO:0005794 IDA
    stereocilium GO:0032420 IEA
    endoplasmic reticulum GO:0005783 IDA
    apical plasma membrane GO:0016324 IDA
 Experiment description of studies that identified ATP8B1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP8B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATP8B1 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases TAS Reactome





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